Figure 2From: Rare coding variants of the adenosine A3 receptor are increased in autism: on the trail of the serotonin transporter regulomeStructure of the A2a adenosine receptor identifying corresponding positions of Leu90 and Val171 residues in the A3 receptor. The structure of the thermostabilized A2a receptor, A2aAR-GL31 (PDB code 2YDO), is depicted as a cartoon in rainbow coloration (N-terminus in blue, C-terminus in red), viewed either (a) parallel to the membrane plane or (b) from the extracellular surface perpendicular to the membrane plane. The endogenous ligand adenosine is shown as a stick model (C, yellow, N, blue, O, red) as is the side chain for Phe168 (C, green). The transmembrane helices are labeled H1-H7, the extracellular loop 2 (EL2) is indicated and H8 is the C-terminal amphipathic helix lying parallel to the membrane plane. A3AR residues Leu90 and Val171 correspond to Val84 and Val171 in A2aAR, and they are both shown as space-filling models (grey).Back to article page