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Table 4 In-silico pathway analysis of proteins with significant diagnosis-age interactions

From: Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders

Top diseases a

P value

Molecules

Hematological disease

1.60E-05 to 1.64E-02

ADIP, CK-MB, CRP, HP, ITAC, MMP-7, TF

Endocrine system disorders

9.51E-05 to 3.71E-02

ADIP, CK-MB, CRP, HP, MMP-7, TF, TG

Top canonical pathway

P value

Ratio

Acute phase response

2.56E-04

3/172

  1. aUniProt accession codes of all 12 proteins with significant diagnosis-age interactions were uploaded into Ingenuity Pathways Knowledge Base (IPKB), and the most over-represented diseases and canonical pathways were determined as described in the Materials and Methods section. The abbreviation of protein names are as indicated in Table 3. The ratio for canonical pathways represents the number of molecules from the data set divided by the total number of molecules in that pathway.
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Molecular Autism

ISSN: 2040-2392