Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders

Table 1 Multiplex immunoassay analysis identification of proteins significantly altered in autism spectrum disorders (ASD)

Analytes	P value	Fold change^a
Tamm-Horsfall urinary glycoprotein	0.004	1.18
Interleukin-3	0.010	0.79
von Willebrand factor	0.023	1.16
Interleukin 12 subunit p40	0.025	0.87
Tyrosine kinase with Ig and EGF homology domains 2	0.033	1.09
Tumor necrosis factor beta	0.034	1.18
Interleukin-13	0.038	0.86
Macrophage derived chemokine	0.042	0.92
Stem cell factor	0.050	0.89

^aGeometric means were used to calculate fold changes (ASD/control) in ASD individuals (n = 37) compared to control (n = 37) subjects. There were no significant differences in age (ASD = 10.9 ± 3.4 years; control = 10.3 ± 3.0 years) or body mass index (BMI) (ASD = 18.0 ± 3.5 kg/m², control = 17.7 ± 3.1 kg/m²). Autism Spectrum Quotient (AQ) scores were significantly different (ASD = 92.0 ± 20; control = 43.9 ± 18; P <0.001). See Table 2 for more detailed demographics. Demographics are reported as mean ± standard deviation.

ISSN: 2040-2392