Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome?

Table 2 Binding parameters from homologous competition binding assays

Binding parameters	Healthy	Fragile X
	(n = 17)^a	(n = 14)^a	% change	P
Receptor density (fmol/mg protein)	1410 ± 421	1683 ± 372	16	0.058
Dissociation constant (nM)	10.6 ± 4.0	10.2 ± 1.6	-4	0.293 ^b
Binding potential (receptor density/dissociation constant)	14 ± 5	17 ± 4	17	0.092

^aValues represent mean ± standard deviation; ^bP value determined from nonparametric Mann–Whitney test.

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