Skip to main content

Table 8 QFAM analyses for family-based association tests for quantitative RRB traits and SLC25A12 SNPs in the SSC sample (n = 720 trio families)

From: A quantitative association study of SLC25A12 and restricted repetitive behavior traits in autism spectrum disorders

 

rs2056202 (na = 720)

rs908670 (n = 718)

rs2292813 (n = 720)

Risk allele (frequency)

A (0.152)

G (0.281)

A (0.107)

Stereotyped behavior

   

βb

0.208

-0.140

0.087

EMP1c

0.004

0.014

0.309

Permutation p

0.004 d

0.014 d

0.316

Self-injurious behavior

   

βb

0.186

-0.171

0.029

EMP1c

0.010

0.003

0.738

Permutation p

0.016 d

0.001 d

0.742

Compulsive behavior

   

βb

0.131

-0.095

0.012

EMP1c

0.070

0.098

0.885

Permutation p

0.072 e

0.083 e

0.883

Ritualistic behavior

   

βb

0.141

-0.036

0.063

EMP1c

0.049

0.532

0.461

Permutation p

0.053 e

0.534

0.471

Sameness behavior

   

βb

0.197

-0.064

0.154

EMP1c

0.006

0.265

0.073

Permutation p

0.008 d

0.270

0.078 e

Restricted behavior

   

βb

0.233

-0.078

0.200

EMP1c

0.001

0.172

0.019

Permutation p

0.001 d

0.162

0.020 d

Sum

   

βb

0.211

-0.115

0.105

EMP1c

0.004

0.046

0.224

Permutation p

0.005 d

0.047 d

0.220

  1. aNumber of subjects with non-missing genotype data available.
  2. bStandardized regression coefficient (negative value indicates negative correlation).
  3. cUncorrected single-point P value.
  4. Permutation p value: dp < 0.05; ep < 0.1.
Back to article page

Molecular Autism

ISSN: 2040-2392