Skip to main content

Table 6 Haplotype analyses for association between quantitative RRB traits and rs2056202-rs908670-rs2292813 haplotype

From: A quantitative association study of SLC25A12 and restricted repetitive behavior traits in autism spectrum disorders

 

UIC-UF sample (n = 179 probands)

SSC sample (n = 720 probands)

Haplotype (frequency)

ATA (0.162)

GCG (0.299)

ATG (0.056)

GTG (0.483)

Omnibus

ATA (0.107)

GCG (0.281)

ATG (0.045)

GTG (0.568)

Omnibus

Stereotyped behavior

          

βb

0.261

0.126

-0.061

-0.212

N/A

0.171

-0.441

1.300

0.064

N/A

Statc

3.150

1.160

0.075

4.300

5.470

0.394

6.010

11.700

0.154

16.100

EMP1d

0.078

0.271

0.782

0.036

0.138

0.524

0.013

0.001

0.700

0.001

Permutation p

0.236

0.656

0.991

0.130

0.138

0.907

0.049 d

0.003 d

0.972

0.001 d

Self-injurious behavior

          

βb

0.276

-0.069

-0.102

-0.058

N/A

0.028

-0.464

1.190

0.151

N/A

Statc

3.260

0.327

0.201

0.285

3.290

0.014

8.730

13.000

1.120

19.600

EMP1d

0.076

0.561

0.649

0.596

0.351

0.907

0.005

0.001

0.289

0.001

Permutation p

0.228

0.927

0.964

0.941

0.351

0.999

0.015 d

0.002 d

0.665

0.001 d

Compulsive behavior

          

βb

0.138

0.200

-0.222

-0.175

N/A

0.016

-0.352

1.230

0.058

N/A

Statc

0.811

2.760

0.963

2.700

4.640

0.002

2.640

7.220

0.087

8.940

EMP1d

0.362

0.099

0.328

0.103

0.202

0.959

0.099

0.007

0.765

0.030

Permutation p

0.772

0.300

0.726

0.310

0.202

1.000

0.307

0.026 d

0.989

0.030 d

Ritualistic behavior

          

βb

0.414

-0.095

-0.096

-0.105

N/A

0.167

-0.114

0.936

-0.139

N/A

Statc

7.620

0.627

0.181

0.974

7.590

0.252

0.269

4.110

0.489

4.560

EMP1d

0.006

0.427

0.675

0.324

0.054

0.619

0.599

0.046

0.489

0.211

Permutation p

0.024 d

0.836

0.969

0.719

0.054 e

0.952

0.947

0.142

0.879

0.211

Sameness behavior

          

βb

0.420

-0.080

-0.156

-0.105

N/A

0.945

-0.378

1.350

-0.280

N/A

Statc

7.600

0.436

0.468

0.942

7.570

3.310

1.200

3.490

0.810

7.630

EMP1d

0.007

0.513

0.502

0.336

0.060

0.071

0.263

0.059

0.368

0.056

Permutation p

0.027 d

0.899

0.890

0.736

0.060 e

0.212

0.645

0.192

0.769

0.056 e

Restricted behavior

          

βb

0.279

-0.046

-0.383

-0.015

N/A

0.454

-0.186

0.624

-0.125

N/A

Statc

3.380

0.143

2.920

0.019

5.430

3.810

1.460

3.700

0.801

8.470

EMP1d

0.066

0.705

0.085

0.893

0.147

0.051

0.225

0.055

0.368

0.038

Permutation p

0.213

0.977

0.270

0.999

0.147

0.164

0.563

0.176

0.770

0.038 d

Sum

          

βb

0.389

-0.045

-0.171

-0.118

N/A

1.450

-1.890

5.960

-0.046

N/A

Statc

6.490

0.137

0.543

1.170

6.520

0.955

3.700

8.150

0.003

11.500

EMP1d

0.012

0.706

0.457

0.276

0.094

0.329

0.056

0.006

0.959

0.009

Permutation p

0.044 d

0.981

0.861

0.656

0.094 e

0.723

0.175

0.019 d

1.000

0.009 d

  1. aStandardized regression coefficient (negative value indicates negative correlation).
  2. bWald test was used to compare tested haplotype with the remaining haplotypes.
  3. cUncorrected single-point P value.
  4. Permutation p value: dp < 0.05; ep < 0.1. N/A: not applicable.