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Table 4 Linear regression analyses for association between quantitative RRB traits and SLC25A12 SNPs after controlling for age, gender, population and FSIQ in the SSC sample

From: A quantitative association study of SLC25A12 and restricted repetitive behavior traits in autism spectrum disorders

Sample

SSC sample (n = 720 probands)

SNP

rs2056202 (na = 714)

rs908670 (n = 712)

rs2292813 (n = 714)

Risk allele (frequency)

A (0.151)

G (0.291)

A (0.102)

Stereotyped behavior

   

βb

0.655

-0.444

0.211

Statc

2.883

-2.499

0.783

EMP1d

0.005

0.012

0.441

Permutation p

0.012 e

0.033 e

0.763

Self-injurious behavior

   

βb

0.484

-0.468

0.044

Statc

2.408

-2.990

0.183

EMP1d

0.016

0.003

0.857

Permutation p

0.044 e

0.008 e

0.995

Compulsive behavior

   

βb

0.531

-0.356

0.055

Statc

1.915

-1.651

0.169

EMP1d

0.057

0.096

0.872

Permutation P

0.132

0.230

0.996

Ritualistic behavior

   

βb

0.491

-0.114

0.183

Statc

1.749

-0.519

0.551

EMP1d

0.077

0.606

0.573

Permutation p

0.186

0.904

0.889

Sameness behavior

   

βb

1.222

-0.377

0.975

Statc

2.797

-1.095

1.880

EMP1d

0.005

0.280

0.061

Permutation p

0.014 e

0.548

0.151

Restricted behavior

   

βb

0.579

-0.188

0.469

Statc

2.953

-1.223

2.019

EMP1d

0.003

0.220

0.042

Permutation p

0.008 e

0.462

0.107

Sum

   

βb

3.485

-1.889

1.615

Statc

2.784

-1.937

1.096

EMP1d

0.005

0.057

0.276

Permutation p

0.015 e

0.135

0.546

  1. aNumber of subjects with non-missing genotype data available.
  2. bStandardized regression coefficient (negative value indicates negative correlation).
  3. cCoefficient t-statistics.
  4. dUncorrected single-point p value.
  5. Permutation p value: eP< 0.05.
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Molecular Autism

ISSN: 2040-2392