Table 2 Common binding domains of autism candidate genes identified by genome-wide association studies-noise reduction (GWAS-NR).
INTERPRO term | No. of genes | INTERPRO identification | P-value1 |
|---|---|---|---|
Immunoglobulin I-set | 20 | IPR013098 | 8.97E-06 |
Cadherin | 16 | IPR002126 | 6.98E-05 |
Cadherin cytoplasmic region | 7 | IPR000233 | 1.14E-04 |
Pleckstrin homology | 26 | IPR001849 | 5.03E-04 |
Immunoglobulin | 21 | IPR013151 | 5.61E-04 |
Immunoglobulin subtype 2 | 21 | IPR003598 | 6.77E-04 |
Fibronectin, type III-like fold | 19 | IPR008957 | 1.19E-03 |
Fibronectin, type III | 19 | IPR003961 | 1.72E-03 |
Epidermal growth factor (EGF) | 14 | IPR006209 | 3.71E-03 |
Meprin/A5-protein/PTPmu (MAM) | 5 | IPR000998 | 6.78E-03 |
Protein-tyrosine phosphatase, receptor/non-receptor type | 7 | IPR000242 | 7.36E-03 |
Pleckstrin homology-type | 24 | IPR001993 | 7.41E-03 |
von Willebrand factor, type A | 10 | IPR002035 | 7.41E-03 |
Immunoglobulin-like | 35 | IPR007110 | 7.57E-03 |