Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry

Table 2 Haplotype transmission disequilibrium results per population across the four genes studied.

Gene	LD block/Tag^b	Hap^a	*IMGSAC*(Multiplex families)				*IMGSAC*(Singleton families)				*Northern Dutch*
Gene	LD block/Tag^b	Hap^a	TR	NT	OR/CI	P -value	TR	NT	OR/CI	P -value	TR	NT	OR/CI	P -value
*LRRN3*	Block 2 (rs10261004-rs214884)	GC									9	26	0.35 (0.16, 0.74)	0.005
*LRRN3*	Block 2 (rs10261004-rs214884)	TT									44	20	2.20 (1.30, 3.73)	0.004
*LRRN1*	Block 3 (rs10510278-rs696489)	AC	98	70	1.40 (1.03, 1.90)	0.037
*LRRN1*	Block 3 (rs10510278-rs696489)	TT	61	85	0.72 (0.52, 1.00)	0.057
*LRRN1*	rs10780025, rs13100776^b	AT	18	37	0.49 (0.28, 0.85)	0.014
*LRRTM3*	rs1925613, rs10762138^b	CT	8	20	0.40 (0.18, 0.91)	0.036
*LRRTM3*	rs1925613, rs1925624^b	AT	139	102	1.36 (1.06, 1.76)	0.020
*LRRTM3*	rs2619652, rs12785206^b	CC					18	7	2.57 (1.07, 6.16)	0.043
*LRRTM3*	rs2619652, rs12785206^b	TT					9	22	0.41 (0.19, 0.89)	0.029
*LRRTM3*	rs1925613, rs12785206^b	CT					8	21	0.38 (0.17, 0.86)	0.024

The analysis was performed within each linkage disequilibrium (LD) block for each gene and for the haplotype combinations from Haploview (selected by Tagger). Only haplotypes^a approaching or below the nominal significance threshold of P < 0.05 are shown.
^aHaplotypes only reported if there are more than 10 informative transmissions in total.
^bHaplotype combinations selected by Tagger.
CI, confidence interval; Hap, Haplotype; NT, non-transmitted; OR, odds ratio; SNP, single nucleotide polymorphism; TR, transmitted.

ISSN: 2040-2392