Skip to main content

Table 2 Linkage signals for insistence on sameness (IS) and repetitive sensory-motor actions (RSMA).

From: Genome-wide linkage analyses of two repetitive behavior phenotypes in Utah pedigrees with autism spectrum disorders

Chromosome

Marker

Boundary (Mb)

Phenotype

Rec

Dom

NPL

2p25.3-p25.1

rs309276

4.11 to 8.13

IS-Adj

2.12

-

2.56

2p25.2-p25.1

rs1560382

4.58 to 9.97

IS

2.00

-

2.56

2q37.1-q37.3

rs1569125

230.89 to 241.89

RSMA

--

2.15

-

2q37.1-q37.3

rs1198823

235.61 to 239.02

IS-Adj

--

2.02

2.57

2q37.1-q37.3

rs1198823

235.61 to 240.61

IS

2.22

3.42**

2.99

3q13.31-q22.1

rs13975

115.07 to 133.09

RSMA-Adj

--

2.02

-

4q31.22-q32.2

rs538317

146.67 to 162.95

IS-Adj

2.39

-

2.91

4q31.23-q32.2

rs2090870

150.39 to 163.91

IS

2.35

-

-

6q22.31-q24.3

rs1041480

125.57 to 148.01

IS

--

-

2.69

8q13.2-q22.1

rs1025908

68.59 to 97.25

RSMA-Adj

--

1.93

-

8q13.2-q22.1

rs2016354

70.19 to 96.31

RSMA

--

2.34

-

9p24.3-p24.1

rs1532309

0.59 to 4.80

IS

2.71

-

-

13q12.12-q12.3*

rs306395

22.86 to 30.07

IS

2.15

-

2.76

15q13.1-q14†

rs904951

27.94 to 31.72

RSMA

3.93

2.68

4.54

15q13.1-q14

rs904951

27.94 to 31.72

RSMA-Adj

4.35

2.19

4.11

15q13.1-q15.1

rs965471

27.94 to 39.04

IS-Adj

2.05

-

-

15q13.3-q15.1

rs965471

29.46 to 38.23

IS

2.00

-

-

15q21.1-q22.2

rs11856

43.47 to 60.20

IS

1.88

-

2.60

15q21.2-q22.2

rs11856

50.79 to 59.13

IS-Adj

3.03

-

3.10

17p13.2-p13.1

rs1848550

5.23 to 9.00

RSMA

2.05

-

-

17q23.2-q24.2

rs1874087

58.03 to 65.40

RSMA-Adj

2.40

-

-

22q13.1-q13.33

rs132817

37.83 to 48.44

RSMA-Adj

--

1.98

-

Xp11.4-q21.33

rs763554

40.14 to 97.88

RSMA

2.61

-

-

Xq13.1-q21.33

rs763554

70.24 to 96.70

RSMA-Adj

3.07

-

-

Xq27.3-q28

rs17318101

142.53 to 154.55

RSMA

1.86

-

-

Xq27.3-q28

rs473491

144.27 to 154.55

IS

1.97

-

-

  1. Dom, dominant; Rec, recessive; IS, insistence on sameness; IS-Adj, IS adjusted for RSMA; RSMA, repetitive sensory-motor actions; RSMA-Adj, RSMA adjusted for IS.
  2. *The nonparametric linkage signal on chromosome 13 for IS shifted slightly downstream: 13q12.12-q13.1, marker = rs1886204, region boundaries = 22.86 to 31.54 Mb.
  3. †The dominant model signal on chromosome 15 for RSMA shifted slightly downstream: 15q13.1-q14, marker = rs2596156, region boundaries = 25.85 to 35.33 Mb.
  4. 'Adj', scale adjusted for the other scale. Signals that are least suggestive [60] are shown for parametric models; for nonparametric linkage (NPL), signals shown are regions where P < 0.005. Bold font for HLOD scores indicates genome-wide significance [60] and for NPL indicates P < 2E-05. Signal boundaries were defined as 1 HLOD or 1 NPL drops from the peak. If linkage at a locus was observed for more than one analysis, boundaries shown are for the recessive model.